Laboratory/Faculty

Laboratory of Cell Regulation
Group of Genetics

ProfessorShizue Ohsawa
Dissecting the mechanism of Tissue growth regulation
Assisitant ProfessorKeisuke Ikawa
Elucidating molecular mechanism of cell delamination on epithelial tissue
Assisitant ProfessorYoshimasa Yagi

▶Laboratory HP
▶Japanese
　　

Multicellular organisms accomplish normal tissue growth in a highly reproducible manner even in the presence of various perturbations such as genetic mutations and environmental fluctuations. Cell-cell communication within the growing tissue ensures robust coordination of tissue growth and homeostasis by regulating cell proliferation and cell death. Using a powerful genetic model Drosophila, we are now dissecting the mechanism of robust coordination of tissue growth and homeostasis through cell-cell communications. In addition, there are growing evidence suggesting that cancer development is also achieved by not only a series of genetic alterations, but also cell-cell communications. We are now dissecting the mechanism of cancer development through cell-cell communication. Our goal is to understand the principle of multicellular communities coordinated by cell-cell communications.

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References

  1. Ohsawa et al., “Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis” Dev. Cell, 44, 284-296 (2018) (Invited Review)
  2. Akai et al., “Wingless signaling regulates winner/loser status in Minute cell competition” Genes Cells, 23, 234-240 (2018)
  3. Yamamoto et al., The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition. Nature, 542, 246-250 (2017)
  4. Nakamura et al., “Mitochondrial defects trigger proliferation of neighbor-ing cells via senescence-associated secretory phenotype in Drosophila” Nature Communications, 5, 5264 (2014)
  5. Ohsawa et al., “Mitochondrial defect drives non-autonomous tumour progression via Hippo signalling in Drosophila” Nature, 490, 547-551 (2012)
  6. Ohsawa et al., “Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila” Developmental Cell, 20, 315-328 (2011)

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