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八木克将


キイロショウジョウバエを主な実験動物として、単独あるいは共同研究で以下のようなテーマについて研究を進めています。

・自然免疫系 を制御するシグナル系の解析
 
多細胞生物は体内に侵入してくる微生物などの「異物」の分子的な特徴を認識して排除するメカニズム、自然免疫系を持って います。このメカ ニズムを明らかにするために、自然免疫系に異常の生じるショウジョウバエ突然変異系統を単離し解析を進めています。

・発生・成長に関わるシグナルの解析


・細胞の未分化状態の維持に関わるメカニズムの解析


○卒業研究、大学院の所属を探している学生の方へ

研究テーマに関しては、1つは私が現在行っているショウジョウバエを実験動物として用いた研究からの課題を行ってもらうことになります。他に は近い実験系、ショウ ジョウバエを用いた研究などで私に指導可能なものであれば相談に応じます。


Publication List
  1. Kato K., Dong B., Wada H., Tanaka-Matakatsu M., Yagi Y., Hayashi S. : Microtubule-dependent balanced cell contraction and luminal-matrix modification accelerate epithelial tube fusion. Nature Comm. (2016) 7 11141 doi:10.1038/ncomms11141

  2. Lim Y.-M., Yagi Y., Tsuda L. : Cellular Defence and Sensory Cell Survival Require Distinct Functions of ebi in Drosophila. PLoS ONE (2015) 10 e0141457.

  3. Moy R.H., Gold B., Molleston J.M., Schad V., Yanger K., Salzano M.-V., Yagi Y., Fitzgerald K.A., Stanger B.Z., Soldan S.S., Cherry S. : Antiviral Autophagy Restricts Rift Fever Virus Infection and Is Conserved from Flies to Mammals. Immunity (2014) 40 51-65.

  4. Yagi Y., Lim, Y.-M. Tsuda L., Nishida Y. : fat facets induces polyubiquitination of Imd and inhibits the innate immune response in Drosophila. Genes Cells. (2013) 18 934-945.

  5. Yagi Y., Nishida Y., Ip Y.T.: Functional analysis of Toll-related genes in Drosophila. Develop. Growth Differ. (2010) 52, 771-783.

  6. Okamoto N., Yamanaka N., Yagi Y., Nishida Y., Kataoka H., O'Connor M.B., Mizoguchi A.: A fat body-derived IGF-like peptide regulates postfeeding growth in Drosophila. Dev. Cell (2009) 6, 885-891.

  7. Yagi Y., Ip Y.T.: Helicase89B is a Mot1p/BTAF1 homologue that mediates an antimicrobial response in Drosophila. EMBO Rep. (2005) 6, 1088-1094.

  8. Craig C.R., Fink J.L., Yagi Y., Ip Y.T., Cagan R.L.: A Drosophila p38 orthologue is required for environmental stress responses. EMBO Rep. (2004) 5 1058-1063.

  9. Bettencourt, R., Tanji, T., Yagi Y. and Ip Y.T. : Toll and Toll-9 in Drosophila innate immune response. J. Endotoxin Res. (2004) 10 261-268.

  10. Hu X., Yagi Y., Tanji T., Zhou S. and Ip Y.T.: Multimerization and interaction of Toll and Spatzle in Drosophila. PNAS (2004) 101 9369-9374.

  11. Ooi J.Y., Yagi Y., Hu X. and Ip Y.T.: The Drosophila Toll-9 activates a constitutive antimicrobial defense. EMBO Rep. (2002) 3 82-87.

  12. Hase M., Yagi Y., Taru H., Tomita S., Sumioka A., Hori K., Miyamoto K., Sasamura T., Nakamura M., Matsuno K. and Suzuki T.: Expression and characterization of the Drosophila X11-like/Mint protein during neural development. J. Neurochem. (2002) 81 1223-1232

  13. Taru H., Iijima K., Hase M., Kirino Y., Yagi Y. and Suzuki T.: Interaction of Alzheimer's β-Amyloid Precursor Family Proteins with Scaffold Proteins of the JNK Signal Cascade.  J. Biol. Chem. (2002) 277 20070-20078.

  14. Yagi Y., Tomita S., Nakamura M. and Suzuki T.: Overexpression of Human Amyloid Precursor Protein in Drosophila. Mol Cell Biol Res Commun. (2000)  4 43-49.

  15. Tomita S., Ozaki T., Taru H., Oguchi S., Takeda S., Yagi Y., Sakiyama S., Kirino Y. and Suzuki T.: Interaction of a Neuron-specific Protein Containing PDZ Domains with Alzheimer's Amyloid Precursor Protein. J. Biol. Chem. (1999) 274  2243-2254.

  16. Yagi Y., Suzuki T. and Hayashi S.: Interaction between Drosophila EGF receptor and vnd determines three dorsoventral domains of the neuroectoderm.  Development. (1998)  125 3625-3633.

  17. Yagi Y. and Hayashi S.: Role of the Drosophila EGF receptor in determination of the dorsoventral domains of escargot expression during primary neurogenesis. Genes Cells (1997) 2 41-53.

  18. Yagi Y., Ishibashi J., Nagata K., Kataoka H., Suzuki A., Mizoguchi A. and Ishizaki H. : The brain neurosecretory cells of the moth Samia cynthia ricini: Immunohistochemical localization and developmental changes of the Samia homolog of the Bombyx prothoracicotropic hormone and bombyxin. Develop. Growth Differ. (1995) 37 505-516.

  19. Ishibashi J., Kataoka H., Isogai A., Kawakami A., Saegusa H., Yagi Y., Mizoguchi A., Ishizaki H. and Suzuki A.: Assignment of Disulfide Bond Location in Prothoracicotropic Hormone of the Silkworm, Bombyx mori: A Homodimeric Peptide. Biochemistry (1994) 33 5912-5919